Wobenzym is a medicinal preparation that contains a combination of enzymes from natural sources. Enzymes are so-called biological catalysts, organic compounds that enable the optimal progress of most reactions in living organisms. There are several thousand kinds of enzymes, and each of them is a dedicated specialist. That is, they act in a certain way only on a certain substance. Only certain enzymes can be used for treatment.

The enzymes that Wobenzym contains positively influence the inflammatory response. They accelerate the absorption of swellings, blood bruises and sprains. They can thus shorten the healing time, thus promoting optimal healing. Wobenzym can therefore also help where a patient suffers from multiple inflammations simultaneously and can therefore be used to treat a wide range of conditions that are caused or accompanied by inflammation.

Natural enzymes against inflammation, swelling and immune disorders

So-called proteolytic enzymes are of particular importance in our body in managing inflammation. They help us to ensure the balance of the immune system so that inflammation passes quickly and without consequences. However, if we have weakened immunity or are threatened by severe inflammation, it is advisable to support our defence system by administering similar enzymes externally. This is dealt with in the special field of medicine systemic enzymotherapy. Years of research have verified the efficacy of the unique blend of proteolytic enzymes contained in the traditional systemic enzyme therapy drug Wobenzym.

Wobenzym gastro-resistant tablets

Read carefullythe full package leaflet before you start taking this medicine as it contains information that is important to you.

- Always take this medicine exactly as directed in this leaflet or as told to you by your doctor or pharmacist.

- Keep this written information. You may need to read it again.

- If you need further information or advice, contact your doctor or pharmacist.

- If you experience any side effect, contact your doctor or pharmacist. This also applies to any side effects not mentioned in this leaflet. See section 4.If you do not feel better or feel worse within 14 days, you must contact your doctor.

In this written information you will learn:

1. What is Wobenzym and what is it used for

2. What you need to know before taking Wobenzym

3. How to take Wobenzym

4. Possible side effects

5. How to store Wobenzym

6. Contents of the package and further information

1. What is Wobenzym and what is it used for

Wobenzym contains appropriately formulated enzymes (protein-breaking substances) that have the ability to effectively influence immunity, reduce inflammation and swelling, and to some extent dissolve blood clots. They accelerate the course of inflammation and alleviate its consequences, suppress the manifestations of the disease caused by harmful immunocomplexes arising as a result of antibody reactions. To the human body, harmful metabolic products and dead tissue material are more quickly degraded. Swellings and blood sprains are better absorbed. Rutin normalizes the permeability of the vascular wall. Wobenzyme reduces blood viscosity and thus improves blood circulation in the finest blood vessels. Tablets are resistant to gastric juice.

Wobenzym is recommended in adults for the following conditions:

- post-traumatic swelling.

- inflammatory and postoperative conditions in surgery.

- lymphoedema (swelling caused by impaired lymph drainage) of various aetiologies.

- fibrocystic mastopathy (a chronic breast disease characterised by the formation of cavities and fibrous tissue).

- post-thrombotic syndrome of the lower limbs (conditions after blockage of the veins of the lower limbs by a blood clot), inflammation of the superficial veins.

- some diseases caused by immunocomplexes (chronic inflammation of joints, muscles, tendons and soft tissues, multiple cerebrospinal sclerosis, inflammation of blood vessels).

- advanced stages of arthrosis (a long-standing, non-inflammatory joint disease that limits joint movement and causes pain)

- chronic and recurrent inflammation (in the nose, ears and throat, upper and lower respiratory tract, urinary and genital tract, joints and others).

- as a supportive therapy in the administration of antibiotics.

2. What you need to know before taking Wobenzym

Do not take Wobenzym

- if you are allergic to any of the active ingredients or to any of the other ingredients in this medicine Wobenzym.

- if you are allergic to fruits such as pineapple or papaya.

- if you have congenital or acquired coagulation disorders such as haemophilia (congenital bleeding disorder) or thrombocytopenia (a morbid reduction in the number of platelets).

Warnings and precautions

Check with your doctor or pharmacist before taking Wobenzym.

This drug does not replace antibiotic treatment for infectious inflammation, but increases their effectiveness. A doctor should be consulted before taking Wobenzym for chronic diseases and when taking it for more than two months.

Occasionally, in chronic diseases, there may be a worsening of symptoms at the beginning of treatment with Wobenzym, which, according to previous experience, is in the vast majority of cases considered to be a manifestation of a positive response of the organism to the treatment. In this case, the drug should not be discontinued, but consideration should be given to possibly temporarily reducing the current dosage. In such circumstances, it is advisable to consult a physician, as well as in the event of the occurrence of side effects or other unusual reactions.

Taking Wobenzyme is not recommended for patients with severe renal or hepatic impairment.

Wobenzym should be discontinued 4 days before dental or any other surgical procedure.

Other medicines and Wobenzym

Adverse interactions of Wobenzyme with other concomitantly administered medications are unknown.

In inflammatory diseases, Wobenzym does not replace antibiotic treatment, but enhances its effect, so it is recommended to consult the attending physician and combine it appropriately with antibiotics.

If you are taking anticoagulants (blood thinners) and/or antiplatelet drugs (blood thinners), talk to your doctor.

If you are now taking or have recently taken any other medicines, tell your doctor or pharmacist.

Wobenzym and food and drink

It is recommended to take the tablets at least 30 minutes before or 90 minutes after a meal with plenty of water (approximately 250 ml).

The gastro-resistant tablet should not be chewed, split or crushed as the coating of the tablet prevents the enzymes in the intestine from degrading.

Pregnancy and breastfeeding

Talk to your doctor about taking Wobenzym during pregnancy, even if you become pregnant during treatment.

Consult your doctor or pharmacist before taking any medicine.

Driving and operating machinery

Taking Wobenzyme does not affect attention while driving and operating machinery.

Wobenzym contains

The drug contains lactose (approximately 160 mg in one tablet) and sucrose (approximately 40 mg in one tablet). If your doctor has told you that you are intolerant to certain sugars, contact your doctor before taking this medicine.

Wobenzym also contains the dyes cochineal red A (E124, Ponceau 4R) and yellow orange S (E110), which can cause allergic reactions, and sodium disulfite (E223), which can rarely cause severe hypersensitivity reactions and bronchospasm (spasm of the bronchial muscles).

This medicine contains less than 1 mmol of sodium (23 mg) per tablet, i.e. an essentially negligible amount of sodium.

3. How to take Wobenzym

Always take Wobenzym exactly as your doctor or pharmacist has told you. If you are unsure about something, check with your doctor or pharmacist.

Depending on the type and acuteness of the disease, treatment is started with a dose of 3 times 5 to 3 times 10 tablets per day. In connection with the retreatment of disease manifestations, the dosage is gradually reduced to a maintenance dose of 3 times 3 tablets per day.

- post-traumatic swelling (bumps, sprains, dislocations, fractures) - we recommend to start treatment with a dose of 3 times 10 tablets per day, depending on the clinical condition (after 7-10 days) the dose is reduced to 3 times 3 tablets per day until the symptoms completely disappear.

- inflammatory and post-operative conditions in surgery - treatment starts with a dose of 3 times 10 tablets daily, after the acute condition subsides (7 - 10 days) until the symptoms subside, continue with a dose of 3 times 5 to 3 times 3 tablets daily.

- lymphoedema (swelling caused by impaired lymph drainage) is a long-term treatment, starting with a dosage of 2 times 10 or 3 times 7 tablets daily (for 4-5 weeks), then reducing to 3 times 5 tablets to 3 times 3 tablets daily (for at least 8 weeks).In this indication, we recommend consulting the attending physician.

- fibrocystic mastopathy (chronic breast disease characterized by the formation of cavities and connective tissue) -we recommend a dosage of 2 times 10 tablets daily for at least 6 weeks. It is advisable to consult the treating physician before starting treatment.

- post-thrombotic syndrome (condition after a vein is blocked by a blood clot) 3 times 10 to 3 times 5 tablets daily for 5-6 weeks.

- inflammation of superficial veins 3 times 7 to 3 times 5 tablets a day for 2-3 weeks.

- chronic inflammation of the joints and spine (rheumatoid arthritis, Bechterew's disease) 3 times 5 tablets daily for 5 - 6 months.

- arthrosis (degenerative joint disease) 3 times 6 tablets a day for 5-6 weeks.

- extra-articular rheumatism 3 times 5 tablets a day for 3-4 weeks.

- multiple cerebrospinal sclerosis (in the stages of attacks and remissions and at the beginning of the chronic progressive stage) 1-14th day 3 times 10 tablets daily, then switching to a maintenance dose of 3 times 3 tablets daily - long-term, in inflammatory conditions (infectious diseases, physical stress, stress, vaccination, sunbathing) the dosage is increased to 3 times 10 tablets daily. It is recommended to consult the attending physician for treatment.

- acute, chronic and recurrent inflammation (in the nose, ears and throat, upper and lower respiratory tract, urinary and genital tract, joints and others). For acute inflammation 3 times 10 tablets daily for 2 weeks, for chronic and recurrent inflammation 3 times 5 tablets daily for 3-4 weeks.

Use in children

The drug is indicated for use in adults and children aged 6 years and older.

In children younger than 6 years, treatment should be started after consideration of the risk-benefit ratio by the attending paediatrician, who will also determine the dosage.

Unless otherwise stated, the daily dose in children should be calculated according to body weight -daily 1 gastro-resistant tablet per 6 kg of weight.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, Wobenzym can cause side effects, although they do not occur in everyone.

Uncommon (may affect more than 1 in 100 people)

- A condition similar to asthma.

- Less often, a bland change in the consistency, color and odor of the stool, diarrhea, nausea, decreased appetite may occur. Feelings of fullness, bloating may occur while taking higher single doses. This can be avoided by dividing the dose into several doses throughout the day and taking the medicine on an empty stomach as recommended. If these symptoms persist after the dose is reduced, consult your doctor.

Rare (may affect more than 1 in 1000 people)

- Vomiting, abdominal cramps

- Anaphylactic reactions, hypersensitivity (hypersensitivity)

- Rarely observed allergic reactions (skin rash, itching, skin redness) subside after discontinuation of the drug. Discontinue taking Wobenzyme and consult your doctor if any of these occur.

Very rare (may affect more than 1 in 10,000 people)

- Abnormal hunger, increased sweating, dizziness, headache, and increased liver enzymes have been very rarely described with treatment. Also consult your doctor about continuing to take Wobenzym if these or any other unusual reactions occur.

Reporting side effects

If you experience any side effect, contact your doctor or pharmacist This also applies to any side effects not listed in this leaflet. You can also report side effects directly to the National Reporting Centre listed in Appendix V.* By reporting side effects, you can help to obtain more information about the safety of this medicine.

5. How to store Wobenzym

Keep this medicine out of the sight and reach of children.

Store in the original packaging at temperatures up to 25 °C.

Bottle: store at room temperature 15-25ºC after first opening.

Do not take this medicine after the expiration date that is listed on the package. The expiry date refers to the last day of the month.

Do not dispose of medicines with waste water or household waste. Return the unused medicine to the pharmacy. These measures will help protect the environment.

6. Contents of the package and further information

What Wobenzym contains

- The drugs are: pancreatin 300 F.I.P.-E (protease, 4000 F.I.P.-E amylase, 4500 F.I.P.-E lipase), trypsin 360 F.I.P.-E, chymotrypsin 300 F.I.P.- E, bromelain 225 F.I.P.- E, papain 90 F.I.P.- E, lipase 34 F.I.P.- E, amylase 50 F.I.P.- E, rutoside trihydrate, 50 mg in 1 gastro-resistant tablet.

total proteolytic activity: 570 F.I.P.-E.

total amylolytic activity: 4030 F.I.P.-E.

total lipolytic activity: 4525 F.I.P.-E.

- Other ingredients are: lactose, magnesium stearate, pregelatinized starch, stearic acid, colloidal silicon dioxide, sucrose, maltodextrin, talc, copolymer of methacrylic acid and methyl methacrylate (1:1), sodium lauryl sulphate, macrogol 6000, triethyl citrate, hypromellose, hydroxypropyl cellulose, microcrystalline cellulose, glycerol, titanium dioxide, cochineal red A (E124, Ponceau 4 R), orange yellow S (E110), sodium disulphite (E 223).

What does Wobenzym look like and the contents of the package

Wobenzym are orange-red, round, lentil-shaped, coated tablets.

Packaging and contents: 40 or 200 tablets in PVC/PE/PVDC/Al, in a paper box or 300 or 800 tablets in a plastic vial with screw cap (clinical packaging).

Marketing authorisation holder

MUCOS Pharma GmbH & Co. KG, Miraustrasse 17, D-135 09 Berlin, Germany

tel: +49(0) 89/638372-0
fax: +49(0) 89/638372-161

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

This written information was last updated in August 2019.